Effects of Mobile Phone Radiation on Human Endothelium
Richard Newton Rooms
Level 5, Electrical Engineering Building
The University of Melbourne
Several animal studies suggested that mobile phone radiation may cause leakage of the blood- brain barrier. Studies of my research group, using cultures of human endothelial cell line, have shown that mobile phone radiation, at levels permitted by the current safety standards, activates Hsp27/p38MAP kinase stress response pathway. Exposure of endothelial cells to mobile phone radiation caused transient increase in phosphorylation (activity) of the Hsp27 stress protein and p38MAP kinase. Activation of the Hsp27/p38MAPK pathway led to re-distribution of the F-actin in cytoplasm and an increased stability of the F-actin stress fibers. This, in turn, led to shrinkage of the endothelial cells. These observations suggest that mobile phone radiation might affect endothelial permeability and potentially cause leakage of the blood-brain barrier. Furthermore, it is likely that the activation of the Hsp27/p38MAPK pathway affects also endothelial gene expression, as shown by the analysis of changes in expression of endothelial transcriptome and proteome. The only human volunteer proteomic study, performed by my research group, has indicated that mobile phone radiation might alter protein expression in human skin. Further studies are necessary to determine whether changes of transcriptome, proteome and blood- brain barrier permeability are caused by mobile phone radiation in human brain.
About Dariusz Leszcynski
Dariusz Leszczynski, PhD, DSc, is an Adjunct Professor of Biochemistry at the University of Helsinki, Finland and Chief Editor of 'Radiation and Health'; specialty of the 'Frontiers in Public Health', an open-access journal published in Lausanne, Switzerland.
He has two doctorates in molecular biology and biochemistry from the Jagiellonian University, Krakow, Poland and Helsinki University, Finland, respectively. For nearly 22 years (1992-2013) he worked at the Finnish Radiation and Nuclear Safety Authority. During the years 2003-2007 he worked as the Head of Radiation Biology Laboratory and from 2000 to 2013 as a Research Professor.
He has spent several periods working at different universities around the world: 1997-1999 - Assistant Professor at the Harvard Medical School, 2006-2009 - Guangbiao Professor at the Zhejiang University School of Medicine, Hangzhou, China and 2012-2013 - Visiting Professor at the Swinburne University of Technology, Melbourne, Australia.
He is an internationally recognized expert in biological and health effects of radiation emitted by the wireless communication devices. Among others, in 2009 he testified in the US Senate and in 2015 in the Canadian House of Commons hearings on cell phones and health and in 2014 he advised Minister of Health of India. In 2011 he was one of the 30 experts, invited by the International Agency for Research on Cancer, who classified cell phone radiation as possibly carcinogenic to humans. His full CV and list of publications are available on his science blog: BRHP – Between a Rock and a Hard Place.
Date: Friday 11 December
Time: 2:00pm - 3:00pm
Venue: Richard Newton Rooms, Electrical Engineering Building, University of Melbourne
RSVP: Fiorella Chiodo, firstname.lastname@example.org